| Excretion occurs primarily in urine, with minute amounl excreted in faeces | Dosage adjustments may be needed |
|---|---|
| — Prevention of acute gouty attacks: Adults: 100 mg daily; increase at weekly intervals by 100 mg without exceeding maximum dose 800 mg , until uric acid level falls to 6 mgll00 ml or less | Dosage adjustment may be needed |
| — Antineoplastics: May increase potential lor bone marrow suppression | Dosage and Administration: — Gout, primary or secondary to hyperuricemia: Dosage varies with severity of diseasecan be given as single dose or In divided doses, but doses larger than 300 mg should be divided |
|---|---|
| Allopurinol is metabolized by xanthine oxidase to oxypurinol which has a plasma half-life of about 15 hours | — The drug should be used with caution in: — pregnancy |
Most of the activity is due to the metabolite oxypurinol, which also is an inhibitor of xanthine oxidase.
13| — Azathioprine, mercaptopurine purinelhoQ: May increase levels of these drugs | Patients are advised to follow a strict exercise and diet regimen along with this medicine to get the best possible effect |
|---|---|
| Children younger than age 6 : 50 mg three times daily | Allopurinol dosage adjustment may be needed |
This is prolonged by renal impairment.
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