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Cohorts 1 to 4, in which patients were categorized as having a non-high or high probability, were combined for a pooled analysis , Cohort 3 The third study cohort comprised consecutive patients with suspected DVT or PE who were included in a study evaluating a new latex D-dimer test HemosIL-D-dimer HS 500, Instrumentation Laboratory
Patients were followed up by a clinic visit or telephone contact at the end of 3 months and were instructed to contact their physician if their leg symptoms worsened or if they developed symptoms suggestive of PE In all studies, the outcome of interest was the development of VTE DVT or PE during 3 months of follow-up in patients in whom DVT was considered excluded after initial diagnostic investigation and who did not receive anticoagulants during follow-up

Using an age

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We then calculated the proportion of patients in whom DVT could be excluded based on a non-high cohorts 1-4 or an unlikely clinical probability cohort 5 together with a normal D-dimer test result — first using the conventional cut-off value, and then using the age-adjusted cut-off value
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Sono inclusi cinque setacci di base, un vassoio di alluminio per essiccare le schiacciate e una retina per essiccare le erbe。 Third, different types of D-dimer tests were used
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Patients were excluded if they were pregnant, received more than 24 hours of anticoagulant therapy at therapeutic doses before presentation or in whom pre-test risk stratification had already been performed by the general practitioner
DVT was ruled out based on: i a non-high clinical probability in combination with a normal D-dimer test result or ii a normal repeated CUS result in patients with a high clinical probability of DVT or an abnormal D-dimer test result — CUS was repeated in patients with normal results on CUS at presentation on days 6 to 8 and days 13-15 Cohort 4 The fourth study was conducted between August 1999 and November 2001 at three hospitals in Ontario, Canada, affiliated with McMaster University in Hamilton
The results and the inclusion and exclusion criteria were published previously Patients with an intermediate clinical probability of DVT and a normal D-dimer test underwent imaging studies at the treating physician's discretion

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Sono inclusi cinque setacci di base, un vassoio di alluminio per essiccare le schiacciate e una retina per essiccare le erbe。 DVT was established based on non-compressibility of the common femoral or popliteal vein with CUS.

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computed tomography in the case of suspected PE or CUS of the leg in the case of suspected DVT
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The study was performed at four hospitals in Bologna Italy , Ottawa Canada , Nice France and Durham South Africa between January 2006 and January 2008
However, we believe that including different study cohorts reinforces the generalizability of our findings The inclusion and exclusion criteria were published previously
Increasing the D-dimer cut-off value did not compromise safety The diagnosis of DVT can be safely excluded based on the combination of a low or intermediate clinical probability combined with a negative D-dimer blood test, in which case imaging studies can be avoided

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The absolute increase in patients in whom DVT could be ruled out i.

النسبة المئوية
Patients with non-high or unlikely probability of deep vein thrombosis were included in the analysis; four different D-dimer tests were used
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It would, therefore, be preferable to be able to exclude the diagnosis of DVT without the need for CUS, especially in the older population of patients
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